Abcam, ab233734, Anti-GRIK3/GluK3 antibody [2B3D1]

Size: 100µg
Mouse Monoclonal GRIK3/GluK3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GRIK3 aa 1-200.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2B3D1,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GRIK3 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q13003

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified from tissue culture supernatant., Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GRIK3 gene encodes the protein GluK3 also known as kainate receptor subunit 3. This protein is involved in mediating synaptic transmission in the central nervous system. GluK3 is part of the ionotropic glutamate receptor family which forms ligand-gated ion channels. The protein has a molecular mass of approximately 107 kDa. GRIK3 is expressed in several regions of the brain including the cortex hippocampus and cerebellum indicating its important roles in these areas.
Biological function summary
The ionotropic receptor family includes GluK3 which forms a functional protein complex known for mediating excitatory neurotransmission. The activity of GluK3 involves the binding of glutamate leading to the opening of cation channels and allowing the flow of sodium and potassium ions. This process results in the depolarization of neurons contributing to synaptic plasticity and excitatory synaptic activity in the brain. The precise functioning of GluK3 is important for maintaining normal synaptic transmission and neuronal communication.
Pathways
The GRIK3/GluK3 protein significantly contributes to the glutamatergic synapse pathway and influences the long-term potentiation (LTP) pathway. GluK3 plays a role in regulating synaptic strength and plasticity by modulating neurotransmitter release and postsynaptic responses. Throughout these pathways it interacts with proteins such as GRIA1 and GRIN2 which are other members of the glutamate receptor family. These interactions ensure proper signal transmission and synaptic adaptation throughout neural circuits.
GRIK3/GluK3 shows associations with psychiatric conditions such as schizophrenia and bipolar disorder. The dysregulation of GluK3 function can lead to aberrant glutamatergic signaling which is implicated in the pathophysiology of these mental health disorders. Furthermore altered GluK3 activity may impact proteins like GRIA2 affecting the overall balance of excitatory and inhibitory signaling in the brain. Understanding the role of GRIK3 in these diseases may help in developing therapeutic interventions.