Abcam, ab234771, Anti-DMXL2 antibody

Size: 100µL
Rabbit Polyclonal DMXL2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DMXL2 aa 2450-2700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DMXL2 aa 2450-2700. The exact immunogen used to generate this antibody is proprietary information.Q8TDJ6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DMXL2 also known as rabconnectin-3α is a large protein with a mass of approximately 350 kDa. It contains multiple WD40 repeats which suggests a role in protein-protein interactions. DMXL2 is expressed in various tissues with higher concentrations in the brain pituitary gland and reproductive organs. It functions mechanically in intracellular transport and signal transduction influencing neurotransmitter release and hormone secretion.
Biological function summary
DMXL2 plays a role in cellular homeostasis and communication. It is part of a protein complex associating with rab3 GTPase-activating proteins to regulate synaptic vesicle exocytosis. This protein contributes to the balance of Ca2+ dynamics in neuronal cells therefore influencing neurotransmitter release processes. Because it interacts directly with components involved in signaling DMXL2 impacts cellular responses to external stimuli.
Pathways
DMXL2 participates in the Notch signaling pathway and mTOR pathway. This protein interacts with key molecules such as rab3 a small GTPase essential for vesicle trafficking. The contribution of DMXL2 to these pathways enables it to orchestrate critical steps in cell growth proliferation and survival. By engaging in these pathways DMXL2 influences cellular metabolism and synaptic plasticity.
DMXL2 shows a connection to polycystic ovary syndrome (PCOS) and neurodegenerative disorders like Alzheimer's disease. Altered DMXL2 expression or function impacts reproductive endocrinology pathways related to PCOS where it can interact with proteins like FSH receptor. In Alzheimer's disease DMXL2's role in synaptic function ties it to amyloid-beta peptide processes an important aspect of the disease's progression. These connections highlight DMXL2 as a potential target for therapeutic intervention in these conditions.