Abcam, ab234812, Anti-RNF126 antibody

Size: 100µg / 100µL
Rabbit Polyclonal RNF126 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human E3 ubiquitin-protein ligase RNF126 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human E3 ubiquitin-protein ligase RNF126 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q9BV68

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RNF126 also known as RING finger protein 126 functions as an E3 ubiquitin ligase. It possesses a molecular mass of approximately 30 kDa and is expressed in various tissues including the brain heart and kidneys. The protein contains a RING finger domain which helps mediate substrate ubiquitination. This post-translational modification marks proteins for degradation by the proteasome regulating protein turnover and function in cells.
Biological function summary
RNF126 plays significant roles in protein homeostasis and cellular stress responses. It interacts with the p97/VCP complex facilitating the extraction of polyubiquitinated proteins from cellular structures for subsequent degradation. Additionally RNF126 regulates the stability of various substrates involved in cellular processes such as DNA repair and the cell cycle. This regulation ensures proper cell function and adaptation to varying environmental conditions.
Pathways
RNF126 participates in the ubiquitin-proteasome system which is critical for the degradation of misfolded or damaged proteins. It also takes part in pathways related to DNA damage response where its function overlaps with proteins like BRCA1 and RAD51. The protein's involvement in these pathways highlights its importance in maintaining genomic stability and proper cellular function. RNF126 ensures proteins are appropriately degraded when no longer needed or damaged maintaining cellular integrity.
RNF126 has been linked to cancer and neurodegenerative diseases. In cancer RNF126 is associated with tumor progression and resistance to therapy potentially through its interaction with proteins such as HER2 and p53. In neurodegenerative diseases impairments in RNF126 function could impact protein clearance contributing to the accumulation of toxic protein aggregates. These relationships suggest that RNF126 might serve as a target for therapeutic intervention in these conditions.