Abcam, ab234856, Anti-DSCR1L1 antibody

Size: 100µL
Rabbit Polyclonal DSCR1L1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RCAN2 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RCAN2 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q14206

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DSCR1L1 also known as RCAN2 (Regulator of Calcineurin 2) is a protein with a molecular weight of approximately 25 kDa. It is encoded by the DSCR1L1 gene and widely expressed in various tissues including the brain heart and skeletal muscles. DSCR1L1 plays a role in inhibiting the phosphatase activity of calcineurin by directly interacting with it. This interaction modulates the intracellular signaling processes that are essential for diverse cellular functions.
Biological function summary
This protein plays an important role in regulating calcium-dependent signaling pathways. Although DSCR1L1 is not typically part of a multiprotein complex it influences pathways through direct and indirect interactions. By inhibiting calcineurin DSCR1L1 limits the dephosphorylation of Nuclear Factor of Activated T-cells (NFAT) proteins which are key transcription factors. This regulation is critical for diverse biological processes including immune response and muscle development.
Pathways
DSCR1L1 modulates the calcineurin-NFAT signaling pathway which is essential for the transduction of calcium signals and the subsequent regulation of gene expression. This protein's interaction with calcineurin affects the transcriptional activity of NFAT proteins which are active in many physiological processes. DSCR1L1 is also connected with the oxidative stress response pathway where it interacts with other proteins that regulate cellular stress responses.
DSCR1L1 has been implicated in neurological conditions such as Down syndrome and Alzheimer's disease. Its regulation of calcineurin activity links it with pathways affected in these disorders. DSCR1L1's relationship with calcineurin also ties it to the pathology of Alzheimer's disease where calcineurin signaling dysregulation is observed. These interactions highlight the significance of DSCR1L1 in processes that contribute to neurodevelopmental and neurodegenerative disorders.