Abcam, ab235569, Pimasertib (AS-703026), MEK1/2 inhibitor

Size: 5mg
MW 431.2 Da, Purity >98%. Pimasertib (AS-703026) is a potent and selective ATP non-competitive inhibitor of MEK1 and MEK2. It displays an IC 50 of 5 nM-2 μM in multiple myeloma cell lines. Growth and survival of U-266 and INA-6 is inhibited with IC 50 of 5 nM and 11 nM, respectively. Induces apoptosis via caspase-3 and PARP cleavage in multiple myeloma cells. Inhibits the ERK pathway, proliferation, and transformation in human DLD-1 colorectal cancer cells what carry the D-MUT mutant allele of K-Ras.
Key facts
CAS number:1204531-26-9,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:431.2 Da,
Molecular formula:C15H15FIN3O3,
PubChem:44187362,
Nature:Synthetic,
Solubility:DMSO 86 mg/mL (199.44 mM)Insoluble in water and ethanol,
Biochemical name:Pimasertib,
Biological description:Pimasertib (AS-703026) is a potent and selective ATP non-competitive inhibitor of MEK1 and MEK2. It displays an IC50 of 5 nM-2 μM in multiple myeloma cell lines. Growth and survival of U-266 and INA-6 is inhibited with IC50 of 5 nM and 11 nM, respectively. Induces apoptosis via caspase-3 and PARP cleavage in multiple myeloma cells. Inhibits the ERK pathway, proliferation, and transformation in human DLD-1 colorectal cancer cells what carry the D-MUT mutant allele of K-Ras.,
Canonical smiles:C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NCC(CO)O,
Isomeric smiles:C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NC[C@@H](CO)O,
InChi:InChI=1S/C15H15FIN3O3/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21/h1-5,7,10,20-22H,6,8H2,(H,19,23)/t10-/m0/s1,
InChiKey:VIUAUNHCRHHYNE-JTQLQIEISA-N,
IUPAC Name:N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B1698 Pimasertib. B1698-25 is the same size as the 25 mg size of ab235569.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this is air sensitive and impurities can occur as a result of air oxidation, Store in the dark, Store under desiccating conditions