Abcam, ab235988, Anti-UGT2B7 antibody

Size: 100µL
Rabbit Polyclonal UGT2B7 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human UGT2B7 aa 200-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human UGT2B7 aa 200-400. The exact immunogen used to generate this antibody is proprietary information.P16662

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UGT2B7 also known as UDP-glucuronosyltransferase 2B7 is an enzyme that helps in the process of glucuronidation. This enzyme has a molecular mass of approximately 56 kDa. It is part of the UGT2B family and is mainly expressed in the liver but also found in other tissues like the kidney and intestines. UGT2B7 plays an important role in metabolizing diverse compounds including drugs and endogenous substances by adding glucuronic acid to them making them more water-soluble and easier to excrete.
Biological function summary
The glucuronidation function of UGT2B7 is important for detoxifying and eliminating hormones bilirubin and xenobiotics from the body. This enzyme does not function as part of a complex; instead it acts individually. The activity of UGT2B7 aids in maintaining homeostasis by processing toxins and facilitating their clearance from the bloodstream. As a member of the large family of UDP-glucuronosyltransferases UGT2B7 exhibits substrate specificity which ensures efficient metabolism of various substrates.
Pathways
UGT2B7 contributes to the drug metabolism pathway and bilirubin clearance pathway. It works closely with other enzymes such as cytochrome P450s which modify the substrates before UGT2B7 adds glucuronic acid. In the drug metabolism pathway the enzyme participates directly in the phase II reaction stages converting lipophilic drug molecules into hydrophilic metabolites. The enzyme's role in bilirubin clearance assists in preventing the buildup of this compound which could lead to harmful conditions.
Faulty UGT2B7 activity correlates with conditions like Gilbert's syndrome and adverse drug reactions. Gilbert's syndrome a mild genetic condition results from reduced glucuronidation capability leading to increased levels of unconjugated bilirubin. The interaction with drugs can also impact their pharmacokinetics and dynamics resulting in toxicity or ineffectiveness. UGT2B7 activity or inhibition directly connects with the response to various drugs underlining its significance in pharmacogenomics and personalized medicine approaches.