Abcam, ab236013, Anti-ARL15 antibody [EPR12591] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal ARL15 antibody. Carrier free. Suitable for IP, WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12591,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab236013 is the carrier-free version of
ab178425
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARL15 also known as ADP-ribosylation factor-like protein 15 is a member of the ARF family of GTPases. This small GTP-binding protein weighs about 21 kDa. ARL15 resides mainly in the cytoplasm but its expression is also notable in adipose tissue and the pancreas. Mechanical interaction of ARL15 with membranes and other molecules is characteristic for proteins in the ARF family indicating a role in cellular functions that involve vesicle trafficking or membrane remodeling.
Biological function summary
ARL15 influences metabolic processes and signaling pathways. It integrates into multiprotein complexes that regulate various cellular activities. Research suggests its involvement in lipid metabolism and adipogenesis playing a role in the regulation of insulin sensitivity. These biological functions make ARL15 significant for maintaining cellular energy balance and metabolic homeostasis.
Pathways
ARL15 engages with two central pathways: the insulin signaling pathway and lipid metabolism. It influences these pathways by interacting with key proteins such as IRS1 in insulin signaling which impacts glucose uptake and energy regulation. Additionally in lipid metabolism ARL15 associates with proteins that control fatty acid oxidation and storage contributing to the overall lipid balance within the cell.
ARL15 has connections to type 2 diabetes and obesity. People with altered expression levels of ARL15 often exhibit changes in insulin sensitivity linking it to the pathophysiology of type 2 diabetes. ARL15 also interacts with PPARγ a protein highly involved in fat tissue development and implicated in obesity. These interactions indicate potential pathways through which ARL15 influences metabolic conditions making it a target of interest for disease research.