Waters Application Kits: Faster, Reproducible LC-MS

Waters Application Kits give you an end-to-end, “ready-to-run” workflow for specific analytes and matrices. Each kit bundles validated consumables and method guidance so you can move from sample to result faster, with fewer variables and more reproducible outcomes across UPLC/LC-MS platforms.

What Are Waters Application Kits?

These kits combine sample-prep components, LC/UPLC columns, vials, standards/reagents, and concise method notes that have been verified to work together. You adopt a proven recipe instead of assembling parts yourself, reducing rework and shortening method development time from the first run.

At a glance (typical contents)

• Sample preparation module (e.g., SPE, digestion, labeling)
• LC/UPLC column(s) and compatible accessories
• Reagents/standards and simple protocols for setup and QC

Core LC-MS Applications & Use Cases

Start by matching your analytical goal to the kit family optimized for that chemistry. Kits span biomolecules and small molecules, covering routine quantification as well as advanced characterization, so you can standardize workflows across teams and instruments with minimal method drift.

• Amino acids in biological samples (derivatization + UPLC separation) — AccQ•Tag Ultra/UPLC AAA.
  
• N-glycan profiling with high sensitivity fluorescence/MS readout — GlycoWorks RapiFluor-MS.
  
• Protein/peptide quantification via surrogate peptides in plasma/serum — ProteinWorks eXpress/Direct Digest.
  
• Oligonucleotide bioanalysis from complex matrices — OligoWorks SPE workflows.
  

How Application Kits Accelerate LC-MS Workflows

You get consistency because critical steps—cleanup, derivatization, digestion, separation—are harmonized under one protocol. Reagents are pre-measured, methods are automation-friendly, and documentation guides validation, which together improves repeatability and shortens the path to reportable data.

Why it’s faster and more reproducible

• Pre-optimized chemistries reduce trial-and-error and batch variability.
• Lot-traceable reagents and defined protocols simplify transfer between sites.
• Automation scripts and plate-based formats speed high-throughput prep.

Product Families: GlycoWorks, AccQ-Tag Ultra, ProteinWorks, OligoWorks

Each family targets a distinct analyte class and preparation strategy. Use the summaries below to quickly narrow choices before you review specific SKUs and method notes.

• GlycoWorks RapiFluor-MS — three-step N-glycan release, labeling, and cleanup with strong fluorescence and MS response; available in multiple sample counts.
  

• AccQ•Tag Ultra/UPLC AAA — robust amino-acid derivatization kits underpinning Waters’ UPLC AAA application solution and UV detection workflows.
  

• ProteinWorks eXpress/Direct Digest — pre-measured digestion reagents and protocols for whole or immunopurified plasma/serum, designed for LC-MS quantification via surrogate peptides.
  

• OligoWorks SPE — WAX-sorbent SPE plates/cartridges plus digestion module and eluents for high oligonucleotide recoveries and enhanced LC-MS performance.

Selection Guide: Choose by Analyte, Matrix & Platform (UPLC/LC-MS)

Use this quick matrix to jump to the right kit family. Filter by what you’re measuring, where it lives, and the prep you prefer; then confirm the matching SKU in the featured table.

Featured Kits & SKUs (Validated Waters Catalogs)

Below are representative kits many labs start with. Each entry lists the family, catalog number, and primary use so you can request a quote confidently and map to your method files.

Compatibility & Required Accessories for LC/UPLC & LC-MS

Before ordering, confirm the instrument class and small accessories that complete the workflow. Kits are designed to fit LC/UPLC and LC-MS methods, and many include vials or specify vial/cap formats to protect integrity from prep to injection.

Checklist

• Verify LC/UPLC system and detector (UV/FLR/MS) match the method.
• Ensure appropriate vials, caps, and column formats are on hand.
• For automation, confirm plate height/format and deck compatibility.

FAQs: Ordering, Storage, Method Notes & Validation

1. Do these kits include methods or just reagents?
They ship with concise method guidance and predefined protocols, so you can replicate conditions quickly without assembling parts from scratch.

2. Can I automate sample prep with these kits?
Yes—several kits and scripts are designed for automation-friendly formats (e.g., plate-based prep and workstation scripts) to increase throughput and consistency.

3. Are refill or alternate-count packs available?
For families like GlycoWorks, you can purchase starter, 96-sample, and refill configurations depending on study scale. Ask us for the SKU that matches your need.

4. What storage/handling considerations apply?
Follow kit-specific guidance included with each product to maintain reagent integrity and lot-to-lot consistency; check expiration and handling notes when your order arrives. (See product pages for details.)

Related Collections: Vials, Standards & Reagents, Columns

If you’re adapting a method or building out a full platform, you’ll likely add consumables from adjacent categories. Exploring these will help you sustain method performance over time and across instruments.

• Vials, Caps & Septa — support clean, consistent injections.
• Standards & Reagents — calibration blends and controls.
• Columns — application-matched UPLC/LC columns for separation stability.

Talk to iRight — Request a Quote

Contact Iright to tell us your analyte, matrix, detector, and desired throughput, and we’ll match the best Waters Application Kit and pack size—plus any columns or accessories you need—to get you running quickly and reproducibly on your LC-MS platform.