Abcam, ab105324, Anti-NALP5 antibody

Size: 100µg
Rabbit Polyclonal NALP5 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NLRP5.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NLRP5. The exact immunogen used to generate this antibody is proprietary information.P59047

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NALP5 also known as NLRP5 or Mater is a member of the NOD-like receptor (NLR) family and has significant mechanical functions in cellular processes. The protein weighs approximately 136 kDa and is mainly expressed in oocytes and early embryos in mammals. Its primary role involves regulation of the innate immune response by detecting intracellular threats and forming inflammasomes. NALP5 contains several important domains including the pyrin domain (PYD) NACHT and leucine-rich repeat domain which contribute to its function in cellular defense mechanisms.
Biological function summary
NALP5 plays critical roles in early embryonic development and successful reproduction. It acts as part of the multiprotein complex known as the inflammasome which is essential for the activation of inflammatory cytokines such as IL-1β. This protein is important for oocyte maturation and early embryogenesis impacting fertility and successful pregnancy outcomes. In the developmental context alterations in the function of NALP5 can affect embryonic cell survival and overall developmental competence.
Pathways
NALP5 is integral in facilitating inflammasome assembly and subsequent activation of inflammatory pathways. It significantly influences the immune response modulation through pathways like the NF-kB signaling pathway. Furthermore NALP5 interacts with proteins such as ASC (apoptosis-associated speck-like protein) to mediate cytokine maturation and inflammation. This protein also connects with caspase-1 a critical component necessary for inflammasome function and cytokine activation.
NALP5 relates directly to autoimmune diseases and reproductive disorders. Altered expression or mutations in NALP5 can result in female infertility and have been studied in the context of autoimmune abnormalities. The protein connects to various disease-associated proteins such as NALP3 and other inflammasome components influencing disease progress in conditions marked by inflammation dysregulation. Understanding the role of NALP5 can therefore provide insights into the pathology of related disorders and open avenues for therapeutic interventions.