Abcam, ab105350, Anti-KPNA6 antibody

Size: 100µg
Rabbit Polyclonal KPNA6 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human KPNA6.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human KPNA6. The exact immunogen used to generate this antibody is proprietary information.O60684,
Specificity:ab105350 is predicted to not crossreact with other Importin alpha family members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KPNA6 also known as importin alpha 7 functions in the nuclear import of proteins. It acts by forming a complex with importin beta allowing proteins to pass through the nuclear pore complex. KPNA6 has a molecular mass of approximately 60 kDa. Expression of KPNA6 occurs in several tissues including liver brain and testes emphasizing its widespread role in various physiological processes.
Biological function summary
KPNA6 facilitates the translocation of proteins containing a nuclear localization signal into the nucleus. It is part of the classical importin alpha/beta complex where it binds cargo proteins and importin beta recognizes the nuclear pore complex. This interaction is essential for the regulation of gene expression DNA replication and cell cycle progression. KPNA6 participates in coordinating these cellular processes by ensuring proteins enter the nucleus with timely precision.
Pathways
Nuclear transport mechanisms involve KPNA6 prominently. It plays a significant role in the nucleocytoplasmic transport pathway also contributing to the regulation of the cell cycle. Proteins related to these pathways include importin beta which partners with KPNA6 for efficient nuclear protein import. These pathways maintain cellular homeostasis and enable response to cellular stress or changes.
KPNA6 links to cancer progression and certain viral infections. Its dysregulation can affect tumor suppressor proteins and oncogenes leading to abnormal cell growth and cancer. KPNA6's interaction with viral proteins like those from HIV highlights its importance in viral pathogenesis where the virus exploits the nuclear import mechanism for replication. Understanding KPNA6 interactions provides insights into therapeutic targets for these conditions.