Abcam, ab105358, Anti-SCUBE1 antibody

Size: 100µg
Rabbit Polyclonal SCUBE1 antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human Signal peptide, CUB and EGF-like domain-containing protein 1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Signal peptide, CUB and EGF-like domain-containing protein 1. The exact immunogen used to generate this antibody is proprietary information.Q8IWY4,
Specificity:ab105358 is predicted to not crossreact with other SCUBE members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCUBE1 also known as Signal Peptide CUB Domain and EGF-Like Domain-Containing Protein 1 is a secreted glycoprotein with a mass of approximately 110 kDa. It plays roles in cell signaling due to its structural domains including the CUB and EGF-like domains. Researchers find SCUBE1 expression mainly in endothelial cells and the early stages of embryogenesis. High levels are present in developing tissues including the heart and neural tube highlighting its significance during development.
Biological function summary
SCUBE1 takes part in modulating cellular signaling and adhesion. It acts as an extracellular matrix protein and may influence interactions between cells and their surrounding matrix. It does not function in isolation and can form complexes with other SCUBE family proteins such as SCUBE2 and SCUBE3 contributing to a range of cellular processes. Evidence indicates its involvement in cardiovascular system development and bone morphogenic protein (BMP) signaling.
Pathways
SCUBE1 participates in BMP and Hedgehog signaling pathways. These pathways are important for various development and maintenance processes in the body. SCUBE1 interacts with BMP-2 and BMP-4 to modulate signal transduction impacting differentiation and patterning during development. The protein also has connections with Indian Hedgehog (IHH) pathway indicating roles in growth plate maturation and vascular formation.
Experts associate SCUBE1 with cardiovascular diseases and neurological disorders. Elevated levels of SCUBE1 are relevant to acute thrombotic events suggesting its role as a biomarker for conditions like acute myocardial infarction. Furthermore SCUBE1 links to neurological disorders through its involvement with Alzheimer's disease. This connection relates to its influence on vascular health and the potential interaction with Amyloid-beta an important protein in Alzheimer's pathology.