Abcam, ab105377, Anti-ATP11B antibody

Size: 100µg
Rabbit Polyclonal ATP11B antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ATP11B.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ATP11B. The exact immunogen used to generate this antibody is proprietary information.Q9Y2G3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATP11B also known as a P-type ATPase acts as a phospholipid transporter that assists in maintaining cellular membrane organization by flipping phospholipids between the inner and outer layers of cell membranes. It has an approximate molecular mass of 150 kDa. This protein is predominantly expressed in the human prostate liver and colorectal tissues. Researchers recognize ATP11B's role in various cellular processes due to its transport activity.
Biological function summary
The ATP11B protein is involved in maintaining the proper distribution of phospholipids across different cellular membranes which is essential for cell membrane stability and function. It often functions as part of a larger protein complex particularly involving transmembrane proteins. This coordination facilitates the efficient movement of specific lipids a process vital for cellular functions like vesicle formation and endocytosis.
Pathways
ATP11B plays a significant role in the vesicular trafficking pathway and lipid signaling pathway. In these pathways ATP11B interacts with other proteins such as CDC50A which serves as an essential subunit for ATPase activity and function. These interactions enable the protein to mediate lipid movement and support various cellular processes including protein sorting and signal transduction.
Research associates ATP11B with cancer progression particularly ovarian cancer and drug resistance mechanisms. ATP11B expression correlates with the development of cisplatin resistance in ovarian cancer cells possibly by altering drug distribution within the cells. Moreover ATP11B might interact with other oncogenic proteins such as MRP2 (Multidrug Resistance Protein 2) contributing to chemotherapy resistance and disease progression.