Abcam, ab105378, Anti-SCUBE2 antibody

Size: 100µg
Rabbit Polyclonal SCUBE2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SCUBE2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SCUBE2. The exact immunogen used to generate this antibody is proprietary information.Q9NQ36

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCUBE2 also known as Signal Peptide CUB Domain EGF-like 2 is a protein carrying a significant role in cellular processes. It has an approximate mass of 123 kDa and identifies as a secreted glycoprotein. SCUBE2 is expressed strongly in tissues such as the heart kidney and brain. Its structure includes several epidermal growth factor-like repeats and CUB domains which help in mediating its interactions in the cellular environment.
Biological function summary
The SCUBE2 protein functions as an important mediator in developmental signal transduction pathways. It does not form part of a well-defined complex but interacts with other proteins to modulate key developmental signals like Hedgehog and BMP pathways. SCUBE2 participates in cell-to-cell communication assisting in the regulation of embryonic development and tissue patterning. This protein's role is essential in ensuring proper growth and differentiation in those developing tissues.
Pathways
SCUBE2 actively engages in the Hedgehog and BMP signaling pathways. These pathways involve critical mediator proteins such as Sonic Hedgehog (SHH) and Bone Morphogenetic Proteins (BMPs) respectively. SCUBE2 interacts with these molecules to influence processes like cellular proliferation and differentiation. By participating in these pathways SCUBE2 influences developmental and cellular mechanisms ensuring proper signaling during morphogenesis and tissue development.
SCUBE2 shows significant associations with various cancers and developmental disorders. For instance alterations in SCUBE2 expression levels have been linked to breast cancer where it may affect cancer cell signaling through interactions with the BMP signaling pathway proteins such as BMP-2. It also associates with developmental disorders influencing the Hedgehog signaling pathway which involves proteins such as GLI1 and affecting proper embryonic development. Understanding SCUBE2's involvement in these diseases could provide new insights into therapeutic strategies.