Abcam, ab106269, Anti-CHL1 antibody

Size: 100µg
Rabbit Polyclonal CHL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CHL1 aa 750-1050.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CHL1 aa 750-1050. The exact immunogen used to generate this antibody is proprietary information.O00533

Properties and Storage Information:
Form-Lyophilized, Reconstitution-Reconstitute in 200 µL of water, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target known as CHL1 also called L1CAM homolog or close homolog of L1 is a transmembrane protein involved in cell adhesion within the nervous system. It has a molecular mass of approximately 140 kDa. CHL1 is mainly expressed in the brain particularly during the development phase including neuronal cell bodies and axonal membranes. Its structural components enable it to facilitate homophilic and heterophilic interactions which are essential for neural cell communication.
Biological function summary
CHL1 plays a critical role in neural development and synapse formation. It is part of the immunoglobulin superfamily and forms complexes with other neural cell adhesion molecules (NCAMs). CHL1 is actively involved in neurite outgrowth cell migration and axonal guidance contributing to the proper formation of neuronal networks. Its expression is tightly regulated during neural development indicating its importance in ensuring correct neural patterning.
Pathways
CHL1 functions significantly in the axon guidance and synaptic plasticity pathways. These pathways are essential for neural differentiation and response to external stimuli. CHL1 interacts with proteins like integrins and cytoplasmic kinases such as focal adhesion kinase (FAK) modulating signal transduction processes that guide axonal development and remodeling. These interactions highlight CHL1's involvement in neural connectivity and adaptability.
CHL1 associates with psychiatric and neurodevelopmental disorders including schizophrenia and autism spectrum disorders. Altered CHL1 expression or function can lead to cognitive and behavioral deficits. Its interaction with proteins like neurofascin further emphasizes its role in maintaining neural network integrity which is often compromised in these disorders. Understanding CHL1’s interactions and functions can provide insights into therapeutic interventions for such conditions.