Abcam, ab106341, Anti-Ultraspiracle antibody

Size: 200µL
Rabbit Polyclonal USP antibody. Suitable for ICC, WB and reacts with Drosophila melanogaster samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Silkworm USP.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Drosophila melanogaster,
Applications:ICC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Silkworm USP. The exact immunogen used to generate this antibody is proprietary information.P49700

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ultraspiracle also known as USP is a nuclear receptor that acts as a transcription factor. It is important in insects often found within the ecdysone receptor complex which occurs in heterodimer form with the Ecdysone receptor (EcR). The protein's mass is approximately 54 kDa. Ultraspiracle generally expresses in insect cells playing an essential role in development and metamorphosis. As part of the ecdysone receptor complex USP binds to specific DNA sequences and regulates gene expression in response to hormonal signaling.
Biological function summary
The ecdysone receptor complex including Ultraspiracle has a significant role in the process of insect molting and metamorphosis. Ultraspiracle as part of this heterodimer with EcR binds to ecdysone response elements on DNA leading to the activation of specific genes necessary for development. This interaction influences various biological processes such as cell cycle regulation and programmed cell death which are important during the transition from larva to pupa and finally to an adult insect.
Pathways
The ecdysone receptor complex involves Ultraspiracle and EcR in the ecdysone signaling pathway which regulates insect development and metamorphosis. The pathway is key in controlling the expression of genes that determine molting and differentiation during developmental stages. USP and EcR interact with other transcription factors and co-regulators to fine-tune the gene expression profiles necessary for these processes. Additionally interactions with proteins like Heat Shock Protein 90 (Hsp90) assist in stabilizing the ecdysone receptor complex ensuring proper signaling.
Ultraspiracle serves as a potential target for research into insect growth regulators aimed at controlling pest species. Modulating the USP activity can disrupt normal development in pests reducing their ability to mature and reproduce. Additionally since USP connects with EcR in hormonal pathways targeting this interaction could lead to novel pesticides that are more specific and environmentally friendly. By understanding the function and interactions of Ultraspiracle researchers can explore new methods for pest control and management.