Abcam, ab106363, Anti-GNPDA2 antibody

Size: 100µg
Rabbit Polyclonal GNPDA2 antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human GNPDA2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GNPDA2. The exact immunogen used to generate this antibody is proprietary information.Q8TDQ7,
Specificity:ab106363 is predicted not to cross-react with GNPDA1.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GNPDA2 protein also known as glucosamine-6-phosphate deaminase 2 has a molecular mass of approximately 33 kDa. It functions mechanically by catalyzing the conversion of glucosamine-6-phosphate to fructose-6-phosphate and ammonia. Its expression occurs in various tissues including the brain liver and adipose tissue. GNPDA2’s enzymatic activity is significant for the regulation of amino sugar and nucleotide sugar metabolism.
Biological function summary
GNPDA2 plays a role in metabolic processes affecting cellular growth and energy production. Although GNPDA2 does not typically form complexes it serves as a single-function enzyme critical to metabolic signaling within cells. Its enzymatic function supports broader cellular activities by mediating sugar metabolism therefore impacting cellular pathways related to metabolism.
Pathways
GNPDA2 contributes to the hexosamine biosynthetic pathway an important route in carbohydrate metabolism. This pathway intersects with the glycolysis pathway and involves enzymes like phosphoglucosamine mutase and hexokinase. GNPDA2’s action in these pathways is important for cellular energy regulation and synthesis of amino sugars necessary for glycosylation processes.
Research links GNPDA2 to obesity and type 2 diabetes. Genetic variants of GNPDA2 have associations with alterations in body mass index impacting metabolic regulation in these conditions. GNPDA2 interacts with proteins such as leptin and insulin which are critical in these disorders affecting metabolic signaling and insulin sensitivity. The protein's role emphasizes its importance in complex metabolic conditions affecting human health.