Abcam, ab106408, Anti-PATT1 antibody

Size: 100µg
Rabbit Polyclonal PATT1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human NAA40.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NAA40. The exact immunogen used to generate this antibody is proprietary information.Q86UY6,
Specificity:At least two isoforms of PATT1 are known to exist; ab106408 will detect both.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PATT1 also known as Protein ABCD1 is a protein involved mechanically in cellular transport functions. It is a transmembrane protein with a mass of approximately 85 kDa. Researchers observe its expression in various tissues with high levels detected in liver and kidney tissues. PATT1 plays an important role in maintaining cellular homeostasis by facilitating the transport of molecules across cell membranes contributing to regulating intracellular environments.
Biological function summary
This protein supports vital processes related to peroxisome function and lipid metabolism. PATT1 associates with a transporter complex involved in importing long-chain fatty acids into peroxisomes. The protein ensures efficient breakdown and metabolism of lipids an important function for meeting cellular energy demands and integrity of cellular membranes. Disruptions in PATT1 activity may compromise fatty acid oxidation and broader metabolic homeostasis.
Pathways
The protein takes part in the peroxisomal beta-oxidation pathway and lipid metabolic pathways. This pathway involves important proteins such as ABCD2 and PMP70 which work alongside PATT1 to accomplish the efficient breakdown of fatty acids. These interactions highlight its role in maintaining energy balance within the cells linking to critical cellular energy production and metabolic processes.
This protein has links to X-linked adrenoleukodystrophy (X-ALD) and certain metabolic syndromes. Mutations or defects in PATT1 impair fatty acid metabolism leading to the accumulation of very long-chain fatty acids. This contributes directly to the development of X-ALD a neurodegenerative disorder. The protein also interacts with ALDP another protein involved in the same metabolic pathway increasing the understanding of disease mechanisms related to fatty acid accumulation and offering potential targets for therapeutic intervention.