Abcam, ab108385, Anti-PRKACG antibody [EP2647Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal KAPCG antibody. Suitable for WB and reacts with Human samples. Cited in 9 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP2647Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody is likely to react with the alpha subunit, as it possesses 85.7% similar homology with the immunogen. Additionally, it may react with the beta subunit, possessing 78.6% homology.

Product details:
The production method for this product has been changed from hybridoma to recombinant on 27th September 2024.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PRKACG also known as Protein Kinase Catalytic Subunit Gamma or cAMP-dependent protein kinase catalytic subunit gamma is a protein involved in kinase activity. This protein has a molecular mass of approximately 40 kDa. PRKACG is expressed in several tissues with notably high expression levels in the brain and testis. It belongs to the protein kinase family and serves a role in transferring phosphate groups from ATP to specific serine or threonine residues on substrate proteins.
Biological function summary
This kinase plays a part in various cellular signaling processes particularly in the regulation of metabolism gene expression and cell differentiation. PRKACG forms part of the larger protein kinase A (PKA) complex which includes regulatory and additional catalytic subunits. This enables precise modulation of cellular responses to different signals important for maintaining homeostasis and responding to environmental changes.
Pathways
PRKACG participates in the cAMP signaling pathway and the long-term depression pathway. In the cAMP signaling pathway it acts with proteins like PRKAR1A and PRKAR2A which serve as regulatory subunits to transmit signals that affect cellular functions. The activation of PRKACG by cAMP leads to phosphorylation events that can change the activity of enzymes involved in energy metabolism and other cellular processes.
PRKACG has connections to psychiatric disorders such as schizophrenia and neurological conditions like Huntington's disease. Alterations in cAMP signaling where PRKACG plays a role can link to these diseases. The interplay between PRKACG and proteins like PRKAR1A may disrupt cellular signaling contributing to the pathophysiology of these conditions.