Abcam, ab110265, Anti-COX6A1 antibody [14A3AD2BH4]

Size: 250µg
Mouse Monoclonal COX6A1 antibody. Suitable for Flow Cyt, WB and reacts with Human, Rat, Mouse samples. Cited in 4 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:14A3AD2BH4,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:ab110265 recognises the Liver isoform in human, rat, mouse.

Product details:
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This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification notes-ab110265 was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
COX6A1 also known as Cytochrome c oxidase subunit 6A1 plays an important role in the electron transport chain by being part of the cytochrome c oxidase (complex IV) in mitochondria. This subunit has a mass of approximately 14 kDa. COX6A1 expresses in various human tissues but shows higher expression in tissues with significant energy demands such as the heart and skeletal muscle. This evidence suggests its critical involvement in cellular energy production.
Biological function summary
COX6A1 contributes to the formation of the cytochrome c oxidase complex which is the terminal enzyme in the mitochondrial respiratory chain. This complex facilitates the transfer of electrons from cytochrome c to oxygen leading to ATP production through oxidative phosphorylation. COX6A1 is an integral component of this complex which exists as part of the inner mitochondrial membrane. It interacts with other subunits to ensure efficient electron transfer and energy conversion.
Pathways
COX6A1 heavily influences the mitochondrial respiratory pathway particularly in oxidative phosphorylation. This pathway includes important components like NADH: ubiquinone oxidoreductase and cytochrome c. COX6A1 bridges interactions within the complex IV with proteins such as COX1 enabling proper electron transport and proton pumping necessary for ATP synthesis. Dysfunction in these interactions may affect overall cellular respiration efficiency.
Mutations and dysregulation of COX6A1 relate to various mitochondrial disorders and neurodegenerative conditions such as Leigh syndrome. Its interactions with other mitochondrial proteins like COX2 and COX3 are vital for maintaining mitochondrial function. Deficiencies in COX6A1 can disrupt proper electron transport leading to decreased ATP production and contributing to pathology in energy-demanding tissues like the brain and muscles.