Abcam, ab111042, Anti-DGKK antibody

Size: 100µg
Rabbit Polyclonal DGKK antibody. Suitable for IHC-P, ICC/IF and reacts with Human, African green monkey samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DGKK aa 1200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, African green monkey,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DGKK aa 1200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q5KSL6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab111042 was affinity-purified from Rabbit antiserum by affinity-chromatography using epitope-specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein diacylglycerol kinase kappa (DGKK) plays a role in the phosphorylation of diacylglycerol to produce phosphatidic acid. This reaction is important in lipid signaling pathways. DGKK has a molecular mass of roughly 135 kDa. It is expressed in various tissues including the brain heart and placenta suggesting that it has functions in diverse physiological processes.
Biological function summary
DGKK functions in the regulation of lipid second messengers which are critical for cellular signaling. It is not known to be part of a specific protein complex but it interacts with other signaling molecules to modulate cellular responses. These interactions suggest DGKK has roles in signaling cascades that control a number of cellular mechanisms.
Pathways
DGKK participates in the glycerolipid metabolism pathway and the signaling events controlled by protein kinase C (PKC). These pathways involve intricate networks of interactions that influence broader cellular functions like cell growth differentiation and apoptosis. DGKK's relationship with PKC is important as both proteins coordinate to regulate the levels of diacylglycerol an important signaling lipid.
DGKK has been implicated in the development of X-linked chondrodysplasia punctata (CDPX2). This disorder which affects bone growth may arise due to disruptions in lipid signaling and metabolism. Additionally research suggests possible associations with neurological disorders though specific connections and mechanisms remain under investigation. Mahajan et al. studied the potential links between DGKK and these conditions providing insights into its roles.