Abcam, ab111572, Anti-LRRC4C antibody

Size: 50µL
Rabbit Polyclonal LRRC4C antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LRRC4C aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LRRC4C aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q9HCJ2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The LRRC4C protein also known as SRR3 or Leucine Rich Repeat Containing 4C plays a role in neuronal signaling. This protein weighs approximately 83 kDa and shows expression predominantly in the nervous system especially in brain tissue. LRRC4C belongs to a family known for containing leucine-rich repeats which are structures involved in protein-protein interactions.
Biological function summary
LRRC4C influences neuronal synapse development and functioning. It interacts with other synaptic components and may form part of larger molecular complexes at the synapse. Its expression and function suggest it might affect synapse formation stabilization and plasticity important for effective neuronal communication and network stabilization.
Pathways
LRRC4C participates in processes involved in synaptic signaling pathways. It closely interacts with proteins such as neuroligins which are important for synaptic adhesion and communication between neurons. These pathways are essential in maintaining the structure and function of synapses contributing to both neuronal growth and signaling efficiency.
LRRC4C shows potential connections to neurological conditions such as autism spectrum disorder and schizophrenia. Studies suggest that its interaction with proteins like neurexins might influence disease pathogenesis given their roles in synaptic organization and function. Disruptions in these pathways can lead to synaptic imbalances contributing to the symptoms associated with these disorders.