Abcam, ab112024, Anti-PDE8B antibody

Size: 100µg
Rabbit Polyclonal PDE8B antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PDE8B aa 800 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PDE8B aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O95263

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PDE8B also known as phosphodiesterase 8B is an enzyme that hydrolyzes cAMP an important second messenger. It plays a significant role in regulating cellular responses to hormonal stimulation by degrading cAMP which in turn modulates cellular signaling. The protein has a molecular mass of approximately 100 kDa. PDE8B expression is high in the thyroid gland and is also found in the brain and testis reflecting its possible various physiological roles.
Biological function summary
PDE8B impacts several critical cellular processes due to its enzymatic role in cAMP degradation. It is a part of the phosphodiesterase enzyme family which includes 11 diverse families of phosphodiesterases. PDE8B's function supports cellular proliferation differentiation and apoptosis control by influencing cAMP levels within the cell. Its activity is not typically associated with any macromolecular complexes but it contributes to the broader regulatory network controlling cAMP-mediated signaling pathways.
Pathways
PDE8B participates in the cAMP signaling pathway which is vital for mediating the effects of neurotransmitters and hormones. The regulation of this pathway by PDE8B affects processes like energy homeostasis inflammation and neurotransmitter release. PDE8B interacts closely with other members of the phosphodiesterase family particularly PDE4 and PDE10 in fine-tuning the cAMP degradation and ensuring precise control of signal transduction.
Mutations in PDE8B are connected to thyroid-related abnormalities such as congenital hypothyroidism. This condition often links to disruptions in cAMP levels impacting thyroid hormone production. Research also suggests a possible association of PDE8B with adrenal diseases where it influences the stress response by affecting cortisol synthesis. In these contexts PDE8B might interact with proteins such as thyroid-stimulating hormone receptor (TSHR) in thyroid conditions and adrenocorticotropic hormone (ACTH) in adrenal functions showcasing its multifaceted role in disease mechanisms.