Abcam, ab113230, Anti-STEAP4 antibody

Size: 50µg
Rabbit Polyclonal STEAP4 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human STEAP4 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human STEAP4 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q687X5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STEAP4 also known as STEAP4 metalloreductase or TIARP is a membrane-associated protein with a molecular mass of approximately 51 kDa. It mainly functions as a metalloreductase playing a role in the reduction of metal ions particularly iron and copper within cells. You find its expression in various tissues with higher levels in the adipose tissue liver and prostate. This protein is integral to cellular processes that require metal ion homeostasis influencing several pathways through its enzymatic activity on metal reduction.
Biological function summary
The function of STEAP4 extends beyond mere metal ion reduction. It contributes to cellular metabolism and inflammatory response regulation. Researchers have noted its involvement in the modulation of reactive oxygen species (ROS) which are important for detoxification and signaling. This protein does not function in isolation but may work in concert with other proteins in complexes related to the cell membrane and energy metabolism.
Pathways
STEAP4 participates in critical metabolic and inflammatory pathways. In particular it plays a role in the JNK and NF-kB signaling pathways which impact cellular stress responses and inflammation. Interactions with additional regulatory proteins such as TNF-alpha and IL-6 further integrate STEAP4 into these pathways linking its functions with larger cellular processes that respond to external stimuli and stress factors.
STEAP4 has important connections to metabolic and inflammatory conditions. Research shows its involvement in obesity-related inflammation and insulin resistance linking it with metabolic syndrome conditions. You also find associations between STEAP4 expression and type 2 diabetes as its dysfunction may impact glucose and lipid metabolism. This protein's interactions with TNF-alpha and IL-6 also suggest a strong link to chronic inflammatory states which can exacerbate metabolic disorders.