Abcam, ab114099, Anti-MSF antibody

Size: 100µg
Rabbit Polyclonal MSF antibody. Suitable for IP, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SEPTIN9 aa 500 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SEPTIN9 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9UHD8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab114099 was affinity purified using an epitope specific to MSF immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MSF also known as Myeloid Differentiation Factor 88 (MYD88) scaffolding factor or stromal cell-derived factor (SDF) is a protein that acts as a signaling molecule. It has an approximate molecular weight of 33 kDa. This protein is important in cell signaling pathways particularly during the immune response. Expression of MSF occurs broadly in immune cells including macrophages and dendritic cells. Its main role is to mediate the cellular response to pathogens by activating downstream signaling pathways.
Biological function summary
MSF functions as a facilitator of signal transduction especially within immune cells. It is not part of a complex but acts as a scaffold bringing together various signaling molecules to enable effective communication within the cell. MSF works to regulate immune responses by interacting with several key proteins involved in pathogen recognition and response promoting the activation of immune-related genes.
Pathways
MSF plays a significant role in the Toll-like receptor (TLR) signaling pathway. It functions to transmit signals from TLRs to activate transcription factors like NF-kB. Additionally MSF is involved in the IL-1 receptor pathway where it interacts with proteins such as Interleukin-1 receptor-associated kinases (IRAKs). These pathways orchestrate inflammatory responses making MSF integral in maintaining proper immune function.
MSF has been associated with autoimmune disorders and certain cancers. Its dysregulation can lead to inappropriate activation of the immune system contributing to conditions such as systemic lupus erythematosus. Some studies have linked MSF with lymphoma where it interacts with proteins like BTK affecting cellular proliferation. Understanding MSF's role in these diseases may provide opportunities for targeted therapies and improved treatments.