Abcam, ab114456, Recombinant Human Kir4.1/KCNJ10 protein

Size: 10µg
Recombinant Human Kir4.1/KCNJ10 protein is a Human Fragment protein, in the 276 to 379 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:SDS-PAGE, ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P78508,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Product details:
This product was previously labelled as Kir4.1.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kir4.1 also known as KCNJ10 is an inwardly rectifying potassium channel. It is a protein with a mass of approximately 45 kDa. Kir4.1 facilitates the movement of potassium ions across the cell membrane helping maintain the membrane potential in certain cells. This channel prominently expresses in the brain kidney and inner ear. In glial cells of the central nervous system it plays an important role in maintaining potassium homeostasis. This is important for the correct functioning of neurons and other glial cells.
Biological function summary
The potassium channel Kir4.1 functions to balance potassium levels in the extracellular space which is important for nerve impulse propagation and muscle contraction. Kir4.1 frequently forms a complex with another potassium channel Kir5.1 (KCNJ16). Together these complexes contribute to fine-tuning the electrochemical gradient impacting various cell types. Its distribution and activity affect neuronal signaling renal function and endolymph generation in the ear.
Pathways
Kir4.1 plays essential roles in neural signaling pathways and renal reabsorption processes. This target interacts with proteins like AQP4 in the brain influencing water transport and ion homeostasis. Its functionality is part of the regulatory mechanisms within the distal convoluted tubule of the kidney impacting water and salt balance. These interactions facilitate proper electrical signaling and osmoregulation in the body.
Kir4.1 has associations with disorders such as epilepsy and EAST syndrome. Defects or dysregulation in the Kir4.1 channel can disrupt potassium ion balance which may lead to abnormal neuronal excitability manifesting as epilepsy. Additionally mutations in this channel can contribute to EAST syndrome a condition involving epilepsy ataxia sensorineural deafness and renal tubulopathy. Related proteins like AQP4 can also be implicated highlighting the complexity of physiological processes involving Kir4.1.