Abcam, ab114550, Recombinant Human KLF6 protein

Size: 10µg
Recombinant Human KLF6 protein is a Human Fragment protein, in the 1 to 261 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q99612,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KLF6 also known as Kruppel-like factor 6 is a transcription factor involved in regulating gene expression. It has a molecular weight of approximately 31 kDa. KLF6 distributes in various tissues including the liver lungs and kidneys where it influences cellular growth differentiation and apoptosis. Researchers often identify this factor by its notable zinc finger DNA-binding motif which facilitates its role in controlling target genes' transcription.
Biological function summary
KLF6 influences several cellular processes by acting as a transcriptional activator. It forms part of larger transcriptional complexes that modulate gene expression in response to specific cellular contexts. For instance KLF6 contributes to cell growth regulation by affecting genes involved in the cell cycle and apoptosis. Its function as a tumor suppressor has gained considerable interest for its involvement in cellular responses to damage and repair.
Pathways
KLF6 interacts with different cellular signaling routes to maintain homeostasis. It plays a significant role in the TGF-β signaling pathway which is important for maintaining cell stability and promoting apoptosis. Additionally it associates with the p53 pathway enhancing its ability to suppress tumor formation. Through these interactions KLF6 works alongside proteins such as SMAD3 and p53 to ensure proper regulation of cellular growth and repair.
KLF6 has associations with cancer and fibrotic diseases. Many studies link reduced or altered KLF6 expression to various human cancers such as prostate and colorectal cancers due to its tumor suppressor function. KLF6 also relates to cardiovascular diseases through its influence on genes associated with fibrosis and inflammation. In these contexts it interacts with other proteins like SMAD3 and TGF-β highlighting its role in disease progression and severity.