Abcam, ab114727, Recombinant Human SCN2A protein

Size: 10µg
Recombinant Human SCN2A protein is a Human Fragment protein, in the 273 to 362 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:Tag free,
Applications:ELISA, SDS-PAGE, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q99250,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SCN2A gene encodes for the Nav1.2 protein a voltage-gated sodium channel alpha subunit with a molecular weight of approximately 260 kDa. This protein acts mechanically by allowing sodium ions to flow into neurons upon depolarization making it fundamental for transmitting electrical signals. Nav1.2 is mainly expressed in the central nervous system especially in the brain regions involved in cognitive functions. Besides Nav1.2 SCI 2A is a popular alternate name for this protein.
Biological function summary
The Nav1.2 channel contributes to the generation and propagation of action potentials in neurons. It is part of a larger sodium channel complex that regulates neuronal excitability and synaptic transmission. This channel plays an essential role in maintaining the electrical activity that supports processes like learning and memory. Proper function of Nav1.2 ensures precise neuronal communication which is necessary for normal cognitive and neurological activities.
Pathways
The Nav1.2 channel integrates into the action potential pathway where it participates in the initiation and transmission of nerve impulses. It also intersects with synaptic transmission pathways working alongside proteins like Nav1.1 and Nav1.6 to ensure proper synaptic function. These interactions facilitate an effective communication system necessary for maintaining neural network stability.
Altered Nav1.2 function associates with epilepsy particularly early-onset epileptic encephalopathies. The gene mutations can disrupt normal sodium channel activity leading to increased neuronal excitability and seizure susceptibility. Furthermore variants in SCN2A link to autism spectrum disorders implicating sodium channel deficiencies in abnormal neurodevelopment. The protein interacts with auxiliary proteins like Navβ1 which influences the severity and presentation of these conditions.