Abcam, ab114738, Recombinant Human LTBP1 protein

Size: 10µg
Recombinant Human LTBP1 protein is a Human Fragment protein, in the 403 to 500 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISA, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q14766,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LTBP1 or Latent Transforming Growth Factor Beta Binding Protein 1 mechanically acts as an important regulator in the activation and release of Transforming Growth Factor Beta (TGF-β). It is part of the latent TGF-β complex binding to TGF-β to help control its availability in the extracellular matrix. LTBP1 has a molecular weight of approximately 190 kDa. The protein is expressed in many tissues including the lung skin and heart highlighting its widespread role in various physiological processes.
Biological function summary
Its main role is modulating the bioavailability and activity of TGF-β a protein important to cellular differentiation proliferation and apoptosis. As part of a larger latent TGF-β complex it determines the precise activation and function of TGF-β by anchoring it to the extracellular matrix. This regulation is important for maintaining tissue homeostasis and has implications in developmental and repair processes across different organ systems.
Pathways
LTBP1 plays a significant role in the TGF-β signaling pathway which is important for controlling cellular growth and differentiation. It is involved in linking TGF-β to large latent complexes impacting its sequestration and activation within the matrix. Through this pathway LTBP1 interacts with proteins such as integrins which help release the active form of TGF-β furthering downstream signaling activities.
LTBP1 is implicated in fibrotic diseases and certain cancers. Abnormal expression or function of LTBP1 can lead to dysregulation of TGF-β activity causing excessive tissue fibrosis as seen in systemic sclerosis or contributing to the progression of cancers like lung carcinoma. The interaction of LTBP1 with other proteins particularly integrins can exacerbate these conditions by derailing typical matrix remodeling and cellular signaling processes.