Abcam, ab114997, Anti-IRF2BP2 antibody

Size: 100µg
Rabbit Polyclonal IRF2BP2 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human IRF2BP2 aa 200-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human IRF2BP2 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.Q7Z5L9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab114997 was affinity purified using an epitope specific to IRF2BP2 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The IRF2BP2 also known as Interferon Regulatory Factor 2 Binding Protein 2 has a mass of approximately 68 kDa. This protein acts mechanically as a transcriptional coregulator. It is involved in the regulation of gene expression by modulating the activity of the transcription factor IRF2. IRF2BP2 is found to be expressed in multiple tissues including the heart spleen and thymus which indicates its broad physiological significance.
Biological function summary
Acting as a transcriptional coregulator IRF2BP2 influences immune response cell differentiation and apoptosis. It functions in conjunction with other cellular components and may form complexes with proteins such as IRF2 and other transcription factors. The protein plays an important role in controlling immune function by either enhancing or suppressing gene expression in response to cellular stimuli.
Pathways
IRF2BP2 involves itself in the immune signaling pathways such as the NF-kB signaling. It also connects to the MAPK signaling pathway which is critical for cellular responses to stress and cytokines. It works closely with proteins such as NF-kB and IRF2 which are significant to these pathways and influence the transcription of target genes.
IRF2BP2 associates with cardiovascular disease and certain inflammatory conditions. In cardiovascular disease this protein may affect heart-related genes mainly through its interaction with IRF2 and possibly through the modulation of inflammatory responses. In inflammatory disorders IRF2BP2 has a regulatory function which involves NF-kB to control excessive inflammatory gene expression influencing disease progression.