Abcam, ab117788, Anti-ANKHD1 antibody

Size: 100µg
Rabbit Polyclonal ANKHD1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ANKHD1 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ANKHD1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q8IWZ3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab117788 was affinity purified using an epitope specific to ANKHD1 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ANKHD1 or Ankyrin Repeat and KH Domain Containing 1 is a protein characterized by the presence of ankyrin repeats and KH domains which suggest its role in protein-protein and protein-RNA interactions. The molecular mass of ANKHD1 is approximately 278 kDa. This protein is widely expressed in various tissues with significant presence observed in the brain liver and kidney. Its structural domains facilitate binding which indicates a potential regulatory function in cellular mechanisms.
Biological function summary
ANKHD1 participates in cellular proliferation and differentiation processes. While it is not solely part of a larger protein complex its interaction with other proteins hints at its role in signal transduction pathways. ANKHD1 interacts with molecules involved in these processes influencing gene expression and cell dynamics which are critical for normal cellular functions and adaptation to stimuli. This protein modulates various signaling cascades which can have broad implications within the cell.
Pathways
ANKHD1 interacts with key signaling pathways notably the PI3K/AKT and Wnt pathways. These pathways are essential for cell growth survival and differentiation. In the PI3K/AKT pathway ANKHD1 can affect the phosphorylation state of proteins altering downstream signal cascades. It also associates with proteins such as β-catenin in the Wnt pathway controlling transcriptional activities that influence cell fate and proliferation. The integration in these pathways underlines its significance in maintaining cellular homeostasis and response.
Researchers have linked ANKHD1 to cancer particularly leukemia and breast cancer. Its involvement in proliferative signaling makes it a candidate for oncogenic processes. ANKHD1 overexpression has been observed in cancerous tissues suggesting its potential role in tumorigenesis. In leukemia its interaction with other oncogenes like BCR-ABL may exacerbate disease progression. Similarly its role in cell survival pathways through relations with proteins like AKT highlightd its impact in cancer biology offering potential targets for therapeutic interventions.