Abcam, ab117927, Anti-AK5 antibody [OTI1D6]

Size: 100µL
Mouse Monoclonal AK5 antibody. Suitable for Flow Cyt, WB, ICC/IF and reacts with Human, African green monkey samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Adenylate kinase isoenzyme 5.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI1D6,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human, African green monkey,
Applications:Flow Cyt, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human Adenylate kinase isoenzyme 5.Q9Y6K8

Product details:
Clone OTI1D6 (formerly 1D6).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant by affinity chromatography., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AK5 or Adenylate Kinase 5 is an enzyme with a specialized role in phosphate group transfer. It functions by catalyzing the reversible transfer of phosphate groups from ATP to AMP which results in the production of ADP. The enzyme has a molecular mass of approximately 26 kDa. AK5 typically shows expression in the brain where it can significantly influence energy transfer and cellular energy balance.
Biological function summary
The function of AK5 involves maintaining energy homeostasis in neural cells. It does not act independently; rather it functions as a part of a larger complex that regulates cellular energetic states. In neural tissues AK5 may have substantial impacts on cellular activity by controlling the levels of key adenylates therefore influencing intracellular signaling pathways.
Pathways
AK5 plays a part in the cellular energy homeostasis pathway and is integral to the purine metabolism pathway. In these pathways AK5 interacts with other adenylate kinases and has associations with enzymes such as AMP-activated protein kinase (AMPK) which acts as an energy sensor. AK5's role in these pathways helps to maintain the balance of adenine nucleotides critical for cellular functions.
Abnormalities in AK5 expression or function can be associated with neurological conditions such as epilepsy. AK5's connection with epilepsy relates partly through its involvement in maintaining proper cellular energetic conditions critical for normal neural activity. It may also relate to metabolic disorders because changes in adenylate kinase function can impact metabolic regulation in the brain. AK5's relationship with AMPK hints at how it might link to these conditions given AMPK's role in detecting cellular energy levels.