Abcam, ab118418, Anti-INPP5A antibody

Size: 100µg
Rabbit Polyclonal INPP5A antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human INPP5A aa 100-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human INPP5A aa 100-350. The exact immunogen used to generate this antibody is proprietary information.Q14642

Properties and Storage Information:
Form-Lyophilized, Reconstitution-Reconstitute in 200 µL of water, Purification technique-Affinity purification Immunogen, Purification notes-ab118418 is purified by a protein affinity column., Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
INPP5A also known as Inositol Polyphosphate-5-Phosphatase A plays a role in cellular signaling by dephosphorylating inositol phosphates. The protein has a molecular mass of approximately 44 kDa. This enzyme mainly expresses in the brain and skin tissues where it carries out its signaling functions. INPP5A acts on substrates such as inositol 145-trisphosphate (IP3) and inositol hexakisphosphate participating in the regulation of various signaling pathways.
Biological function summary
INPP5A enzymes regulate calcium signaling and apoptosis through their phosphatase activity. By removing phosphate groups INPP5A enzymes contribute to the termination of inositol phosphate signaling which affects a wide variety of cell processes. This enzyme functions as a singular unit rather than part of a larger enzyme complex allowing it to target inositol phosphates independently. The control of these signaling pathways is important for maintaining proper cellular function and communicating signals within cells.
Pathways
INPP5A contributes to the phosphoinositide signaling pathway and calcium signaling pathway. Its phosphatase activity provides an important regulatory function modulating the levels of inositol phosphates and thereby affecting downstream signaling processes like calcium release. It relates to proteins such as IP3 receptors and other inositol phosphatases emphasizing its role in orchestrating complex signaling networks within cells.
Alterations in INPP5A activity have connections to spinocerebellar ataxia and certain skin disorders like psoriasis. Disrupted INPP5A expression or function can interfere with normal cellular signaling potentially leading to neurological symptoms or skin pathologies. In the context of these diseases INPP5A shows interactions with proteins involved in neurodegeneration and epidermal regulation highlighting its significance in maintaining homeostasis and disease prevention.