Abcam, ab118569, Anti-IRGM antibody

Size: 50µg
Rabbit Polyclonal IRGM antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human IRGM.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human IRGM. The exact immunogen used to generate this antibody is proprietary information.A1A4Y4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle, Store undiluted

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IRGM also known as Immunity-Related GTPase Family M is a small protein with a molecular mass of approximately 22 kDa. This protein is mostly expressed in immune cells such as macrophages and dendritic cells. IRGM engages in autophagy a cellular process that eliminates intracellular pathogens and maintains cellular homeostasis. Its involvement in autophagy makes it an important player in immune defense mechanisms.
Biological function summary
IRGM functions to regulate innate immune responses. It is part of the ATG (autophagy-related) complex where it facilitates the formation of autophagosomes. This protein initiates the degradation of microbial invaders and damaged organelles contributing to the host defense systems. IRGM can also modulate inflammatory responses by interacting with other immune components ensuring a balance between pathogen clearance and tissue damage prevention.
Pathways
IRGM holds a connection to the autophagy pathway where it works together with proteins like LC3 and p62/sequestosome 1. This pathway is important for the degradation of pathogens engulfed in autophagosomes. In addition IRGM is involved in the intracellular signaling pathways that respond to bacterial infections collaborating with NOD2 and other pattern recognition receptors to enhance immune response.
IRGM has shown links to Crohn's disease and tuberculosis. Crohn's disease a type of inflammatory bowel disease sees IRGM influencing autophagy pathways which affects the host's ability to handle gut microbiota and microbial pathogens. In tuberculosis IRGM helps control Mycobacterium tuberculosis infection through autophagy-mediated pathways. Disruptions in IRGM functions can impair effective autophagic response influencing the progression of these diseases.