Abcam, ab120122, 4-Aminopyridine (4-AP), K+ channel blocker

Size: 100mg
MW 94.11 Da, Purity >99%. Potassium channel blocker. Blocks Kv channels. Convulsant, and useful tool to model epileptiform activity *in vitro*.
Key facts
CAS number:504-24-5,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:94.11 Da,
Molecular formula:C5H6N2,
PubChem:1727,
Nature:Synthetic,
Solubility:Soluble in water to 100 mM,
Biochemical name:4-Aminopyridine,
Biological description:Potassium channel blocker. Blocks Kv channels. Convulsant, and useful tool to model epileptiform activity *in vitro*.,
Canonical smiles:C1=CN=CC=C1N,
InChi:InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7),
InChiKey:NUKYPUAOHBNCPY-UHFFFAOYSA-N,
IUPAC Name:pyridin-4-amine

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kv2.2 also known as KCNB2 KCNA10 KCNA5/KV1-5 and Kir7.1/KCNJ13 are voltage-gated potassium channels. Mechanically these channels mediate the flow of potassium ions across the cell membrane important for cellular excitability. Kv2.2 in particular has a molecular mass of about 104 kDa. It is widely expressed in various tissues including the brain and heart where it plays a significant role in repolarization of the action potential and in modulating electrical signaling in neurons and cardiac cells.
Biological function summary
Kv2.2 and its related family members influence the physiological functions of cells by stabilizing resting membrane potential and regulating neurotransmitter release. Kv2.2 channels are often part of larger channel complexes interacting with other proteins to form functional units that respond to changes in membrane potential. These channels significantly affect cellular excitability and signal propagation and are sensitive to pharmacological agents like 4-aminopyridine a known blocker of potassium channels.
Pathways
Kv2.2 channels participate in critical signaling pathways such as those related to neurotransmission and cardiac rhythm maintenance. The MAPK pathway is one area where Kv2.2 functions integrating signals that modulate cell activity. Related proteins include KCNA1 and KCNQ2 which share roles in maintaining electrical gradients and facilitating rapid signaling across excitable membranes.
Kv2.2 channels have been implicated in conditions such as epilepsy and cardiac arrhythmias. Disruption in Kv2.2 function can lead to abnormal neuronal firing contributing to epileptic seizures. Similarly in cardiac tissues dysfunctions in these channels may result in arrhythmias. The Kv1.1 and Kv3.1 proteins are related to these disorders through their shared responsibility in regulating electrical activity highlighting the importance of potassium channels in normal physiology and pathophysiology.