Abcam, ab214205, Anti-Mitochondrial dicarboxylate carrier antibody

Size: 100µL
Rabbit Polyclonal Mitochondrial dicarboxylate carrier antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC25A10 aa 200-250 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC25A10 aa 200-250 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q9UBX3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The mitochondrial dicarboxylate carrier also known as the dicarboxylate transporter facilitates the exchange of dicarboxylates across the mitochondrial inner membrane. This carrier protein often termed the dicarboxylate carrier or oxodicarboxylate transporter possesses a molecular mass of approximately 31 kilodaltons and is expressed predominantly in metabolically active tissues such as liver kidney and heart. Its key function lies in transporting four-carbon dicarboxylates like succinate and malate important for energy and metabolic equilibrium.
Biological function summary
The mitochondrial dicarboxylate carrier aids in mitochondrial processes by mediating the shuttle of dicarboxylates important for the tricarboxylic acid (TCA) cycle and urea cycle. It actively participates in the transfer of metabolites that contribute to the synthesis of ATP linking important metabolic routes. The dicarboxylate carrier operates as a part of the family of mitochondrial transport proteins but does not form part of a larger protein complex.
Pathways
The dicarboxylate carrier intersects several key metabolic pathways including the TCA cycle and gluconeogenesis. Through these pathways the protein collaborates with others like the adenine nucleotide translocase; it aids in maintaining energetic homeostasis within cells. The correct functioning of the dicarboxylate carrier ensures the proper flow of carbon skeletons essential for cellular respiration and energy production.
The malfunction of the mitochondrial dicarboxylate carrier links to metabolic conditions like renal tubular acidosis and certain forms of mitochondrial myopathy. The carrier's dysfunction may result in disrupted acid-base homeostasis within the kidneys due to impaired succinate transport. In these contexts proteins such as the mitochondrial pyruvate carrier may exhibit interconnected roles further influencing pathological states. Understanding the carrier's activity impacts strategies for addressing metabolic dysregulations associated with mitochondrial diseases.