Abcam, ab216413, Anti-Nociceptin antibody

Size: 100µL
Rabbit Polyclonal Nociceptin antibody. Suitable for WB, IHC-P and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PNOC aa 100-150 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PNOC aa 100-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q13519

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Nociceptin also known as Orphanin FQ is a neuropeptide that functions as a ligand for the nociceptin receptor (NOP receptor or ORL1). It is a peptide made of 17 amino acids with an approximate mass of 2 kDa. Nociceptin is widely expressed in the central and peripheral nervous systems including the brain spinal cord and peripheral sensory neurons. It is involved in modulating various physiological processes through interaction with its receptor influencing neuronal excitability and synaptic plasticity.
Biological function summary
Nociceptin impacts pain modulation stress response and behavioral regulation. It forms a signaling complex with the NOP receptor which is a member of the opioid receptor family. Unlike classical opioid peptides nociceptin does not bind to opioid receptors (mu delta or kappa) and is considered to have a distinct role in the nervous system. Its action can be anti-opioid or analgesic depending on the context of its expression and the physiological state influenced.
Pathways
Nociceptin plays a significant role in nociceptive pathways and stress-related pathways. In the nociceptive pathways it regulates pain transmission through its interaction with the NOP receptor which can inhibit neurotransmitter release and hyperalgesia. Related proteins in these pathways include neurotransmitters like substance P and calcitonin gene-related peptide (CGRP). In stress-related pathways nociceptin interacts with components involved in the hypothalamic-pituitary-adrenal (HPA) axis modulating stress hormone release and affecting behavioral responses to stress.
Nociceptin has been linked to chronic pain conditions and anxiety disorders. Its dysregulation can contribute to altered pain perception seen in chronic pain syndromes with connections to proteins like cyclooxygenase (COX) in the peripheral inflammation response. In anxiety disorders nociceptin's influence on behavioral responses to stress relates to pathways involving corticotropin-releasing factor (CRF) which also interacts with the HPA axis. By understanding these connections researchers aim to explore nociceptin as a potential therapeutic target for these disorders.