Abcam, ab216983, MCAAD-3, Near-infrared probe for imaging of amyloid plaques

Size: 5mg / 10mg
MW 282.34 g/mol, Purity >99%. Near-infrared probe for imaging of amyloid plaques in Alzheimer's disease. DANIR 2c analog that shows extended emission wavelength and significant reduced binding affinity to Aβ aggregates compared with DANIR 2c . In vivo imaging studies suggest that MCAAD-3 can penetrate the blood–brain barrier and label Aβ plaques in the brains of transgenic mice.
Key facts
CAS number:1625629-51-7,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:282.34 g/mol,
Molecular formula:C17H18N2O2,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biological description:Near-infrared probe for imaging of amyloid plaques in Alzheimer's disease. DANIR 2c analog that shows extended emission wavelength and significant reduced binding affinity to Aβ aggregates compared with DANIR 2c. In vivo imaging studies suggest that MCAAD-3 can penetrate the blood–brain barrier and label Aβ plaques in the brains of transgenic mice.,
Isomeric smiles:CN(C)C1CCC(/C=C/C=C/C=C(/C#N)C(=O)OC)CC1,
InChi:InChI=1S/C17H18N2O2/c1-19(2)16-11-9-14(10-12-16)7-5-4-6-8-15(13-18)17(20)21-3/h4-12H,1-3H3/b6-4+,7-5+,15-8-,
IUPAC Name:methyl (2Z,4E,6E)-2-cyano-7-[4-(dimethylamino)]hepta-2,4,6-trienoate

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C