Abcam, ab217044, Anti-SPOCK2 antibody

Size: 100µL
Rabbit Polyclonal SPOCK2 antibody. Suitable for IHC-P, WB and reacts with Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SPOCK2 aa 100-150 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SPOCK2 aa 100-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q92563

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SPOCK2 also known as Testican-2 is an extracellular matrix glycoprotein with a molecular mass of approximately 51 kDa. This protein is predominantly expressed in the nervous system particularly in the brain and also found in other tissues such as lung and heart. It possesses calcium-binding domains and regions associated with protein-protein interactions which contribute to its functional activities in cellular environments. SPOCK2's structure suggests it may play a role in modulating cellular communication by interacting with other matrix components.
Biological function summary
SPOCK2 influences cellular interactions and tissue development. It is a component of the extracellular matrix facilitating cell adhesion and migration. Additionally SPOCK2 can regulate protease activity thereby influencing tissue remodeling processes. In some contexts SPOCK2 interacts with other extracellular matrix proteins like tenascin and fibronectin which suggests its involvement in extracellular signaling pathways that guide cellular responses during development and repair.
Pathways
SPOCK2 participates in signaling and structural pathways linked to cellular growth and repair. It engages in pathways like the integrin signaling pathway important for cell adhesion and migration and plays a role in the Hedgehog signaling pathway that regulates developmental processes. Related proteins within these pathways include integrins and patched receptors which interact with SPOCK2 to modulate cellular responses and determine structural organization within tissues.
SPOCK2 has associations with glioblastoma and asthma. In glioblastoma SPOCK2 interacts with matrix metalloproteinases contributing to tumor progression and invasion. Additionally this protein's regulatory effects on protease activity can influence airway remodeling in asthma linking it to inflammatory responses. The functional dynamics of SPOCK2 in these diseases highlight its involvement with proteins like MMPs and cytokines emphasizing its impact on disease progression and progression mechanisms.