Abcam, ab217360, Anti-LIPC antibody

Size: 100µL
Rabbit Polyclonal LIPC antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human LIPC aa 300-400 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LIPC aa 300-400 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P11150

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LIPC also known as Hepatic Lipase plays an important role in lipid metabolism. LIPC has a molecular mass of approximately 56 kDa. It is primarily expressed in the liver and facilitates the hydrolysis of triglycerides and phospholipids in lipoproteins. By acting on lipid substrates LIPC aids in the conversion of intermediate-density lipoproteins (IDL) to low-density lipoproteins (LDL) and helps maintain a balance of plasma lipoproteins.
Biological function summary
The protein contributes to the remodeling of high-density lipoproteins (HDL) and acts in concert with other enzymes to regulate lipid levels in the bloodstream. LIPC functions as a monomer and not as part of a larger complex. Its enzymatic activity impacts the size and composition of HDL particles influencing reverse cholesterol transport. This functional role makes it significant in lipid transport and overall cholesterol homeostasis.
Pathways
LIPC integrates into the lipid and lipoprotein metabolism pathway and the cholesterol biosynthesis pathway. It interacts closely with proteins like Apolipoprotein E (ApoE) and Apolipoprotein C-II (ApoC-II) which modulate its activity and lipid processing capabilities. LIPC's role in converting IDL to LDL connects it to the broader context of lipoprotein metabolism influencing cholesterol transport and clearance mechanisms.
LIPC links to cardiovascular diseases and metabolic syndrome. Abnormal LIPC activity may lead to altered lipoprotein profiles and contribute to atherosclerosis development. Through this context LIPC indirectly associates with the Low-Density Lipoprotein Receptor (LDLR) as both are involved in lipid level regulation and cardiovascular health. Understanding LIPC's implications in these conditions can aid in therapeutic strategies targeting lipid abnormalities.