Abcam, ab219122, Recombinant human FGF6 protein (Active)

Size: 5µg / 25µg / 100µg
Recombinant human FGF6 protein (Active) is a Human Fragment protein, in the 41 to 208 aa range, expressed in Escherichia coli, with >95%, <1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>95% SDS-PAGE,
Endotoxin level:<1 EU/µg,
Expression system:Escherichia coli,
Tags:Tag free,
Applications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Determined by NR6R-3T3 Proliferation with 1 ug heparin.ED50 ≤1 ng/ml (≥ 1.0 x 106 units/mg).,
Accession:P10767,
Animal free:No,
Carrier free:Yes,
Species:Human,
Reconstitution:Reconstitute at 0.1 mg/mL in water,
Storage buffer:Constituents: 0.29% Sodium chloride, 0.16% Sodium phosphate

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FGF6 also known as Fibroblast Growth Factor 6 is a protein that plays an important role in muscle development and repair. It has a molecular mass of approximately 23 kDa. Researchers find FGF6 to be expressed mainly in skeletal muscle tissue indicating its specific role in muscular activities. Apart from muscle tissues evidence also suggests its expression in certain brain areas contributing to its diverse functions.
Biological function summary
FGF6 belongs to the fibroblast growth factor family which is essential for cell proliferation and differentiation. It significantly influences muscle regeneration and repair after injury. Though FGF6 acts independently it often interacts with FGF receptors on the cell surface to stimulate cellular responses. Its activity does not limit to isolated action but integrates well with complex cellular processes important for muscle tissue maintenance.
Pathways
FGF6 plays a role in signaling cascades such as the MAPK/ERK pathway that regulates various cellular activities like proliferation and differentiation. This pathway involves important interactions with proteins like FGFR1 a receptor that mediates FGF6's effects. Crosstalk with the PI3K/AKT pathway further enhances cellular survival and growth showing the broad involvement of FGF6 in musculoskeletal pathway networks.
Researchers link FGF6 to conditions such as muscular dystrophy and certain types of cancers. Its involvement in muscular dystrophies highlights its role in improper muscle repair and maintenance. In cancer FGF6 may contribute to tumor growth and progression due to its proliferative effects. Proteins like FGFR1 play a role in mediating FGF6’s influence in these diseases providing critical insights into potential therapeutic targets.