Abcam, ab219854, Anti-CCPG1 antibody

Size: 100µL
Rabbit Polyclonal CCPG1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CCPG1 aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CCPG1 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.Q9ULG6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CCPG1 also known as cell cycle progression 1 is a protein that plays an essential role in cellular functions. It has a molecular mass of about 81 kDa. This protein regulates the cell cycle and modulates transcriptional activation which is important for cell division and growth. CCPG1 is expressed in several tissues including liver and skeletal muscles indicating its importance across various biological processes. Its regulation impacts cell cycle phases particularly the transition from G1 to S phase which ensures proper cell division and function.
Biological function summary
CCPG1 serves an important role in maintaining cellular homeostasis and participates in endoplasmic reticulum (ER) stress response. It acts as a mediator for autophagy where it assists in disposing of misfolded proteins. CCPG1 works as a part of a complex machinery interacting with other molecules to ensure that autophagic processes run smoothly in stress conditions. The protein also modulates interactions with the Golgi apparatus and influences protein traffic further emphasizing its broad impact on cellular mechanics.
Pathways
Studies demonstrate that CCPG1 contributes significantly to the autophagy pathway where it interacts with key proteins like LC3. This protein's involvement in endoplasmic-reticulum-associated degradation (ERAD) connects it to proteostasis pathways working alongside proteins like ATG16L1 to maintain cellular equilibrium. CCPG1 influences these pathways by facilitating degradation of misfolded proteins which aids in maintaining cellular stress responses.
Multiple researchers linked CCPG1 to neurodegenerative conditions like Alzheimer's disease. Its role in autophagy and protein homeostasis suggests a connection to neurodegeneration potentially because disrupted CCPG1 function might lead to accumulation of toxic proteins. Additionally CCPG1 displays a relationship with inflammatory disorders where improper regulation could increase cellular inflammation. In both contexts CCPG1 interacts with key proteins involved in disease mechanisms such as ATG5 in autophagy or NF-κB in inflammation.