Abcam, ab219957, Anti-ZNF367 antibody

Size: 100µL
Rabbit Polyclonal ZNF367 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF367 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF367 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q7RTV3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF367 also known as zinc finger protein 367 or ZCWCC1 is a protein that acts in transcriptional regulation. It contains multiple zinc finger domains which enable it to bind to DNA and influence gene expression. ZNF367 has a mass of approximately 34 kDa. Researchers have detected its expression primarily in the nucleus of various cell types suggesting its widespread role across different tissues.
Biological function summary
ZNF367 plays an important role in the regulation of cell cycle and maintenance of cellular proliferation. It does not form part of any known larger protein complex but influences the transcription of several genes associated with cell division. Through its activity ZNF367 supports processes such as tumorigenesis and embryonic development where precise control of cell proliferation is critical.
Pathways
The action of ZNF367 involves significant interactions within the cell cycle regulation and differentiation pathways. It frequently associates with the p53 signaling pathway which controls cell cycle arrest and apoptosis. ZNF367 interacts with proteins like MDM2 an E3 ubiquitin-protein ligase to modulate cell cycle dynamics and survival balancing cell growth with genetic integrity.
ZNF367 has notable implications in cancer particularly in breast and ovarian cancers. Its dysregulation leads to unchecked cell proliferation contributing to tumor growth and progression. ZNF367 is connected to ERBB2 also known as HER2 frequently overexpressed in certain breast cancers indicating its potential involvement in oncogenic pathways. Furthermore potential links to neurodevelopmental disorders highlight its role in neuron differentiation and brain function although these connections require further study to fully understand the mechanisms involved.