Abcam, ab219978, Anti-Epigen antibody

Size: 100µL
Rabbit Polyclonal Epigen antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EPGN aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EPGN aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q6UW88

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Epigen protein also referred to by its gene name EPGN is a member of the epidermal growth factor (EGF) family. This protein has a molecular mass of approximately 19 kDa and is known for being expressed in several tissues with notable expression in the liver and heart. Its structure includes a single EGF-like domain that plays a role in its functional interaction with other cellular components.
Biological function summary
Epigen is involved in promoting cell proliferation and differentiation. It interacts with the epidermal growth factor receptor (EGFR) triggering downstream signaling pathways that influence cell growth. While Epigen acts independently it may have interactions that suggest participation in broader molecular complexes. These interactions contribute to its role in various physiological processes such as tissue repair and maintenance.
Pathways
Epigen engages in the EGFR signaling pathway an essential mechanism for regulating cell division and survival. This pathway includes proteins such as EGFR and its downstream effectors like the MAPK and PI3K pathways. Through these pathways Epigen influences cellular responses to growth signals effectively linking extracellular cues to intracellular actions.
Epigen is associated with cancer and cardiovascular diseases. Abnormal expression or activity of Epigen can lead to enhanced cell proliferation a hallmark of oncogenesis. Its interaction with proteins like EGFR has been implicated in tumor progression and metastasis. In cardiovascular conditions Epigen’s regulatory role on cardiac cells ties it to disorders where cell proliferation is disrupted or improperly controlled.