Abcam, ab220021, Anti-HORMAD1 antibody

Size: 100µL
Rabbit Polyclonal HORMAD1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HORMAD1 aa 250-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HORMAD1 aa 250-350. The exact immunogen used to generate this antibody is proprietary information.Q86X24

Product details:
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HORMAD1 also known as Hormad Homolog 1 serves as an important player in the meiotic process. It has a molecular weight of approximately 38 kDa. HORMAD1 expression is largely restricted to the testis and ovary specifically during meiosis where it plays an essential role. This protein assists in homologous chromosome pairing and alignment thereby contributing to the stabilization of the synaptonemal complex during prophase I of meiosis.
Biological function summary
HORMAD1 ensures the proper progression of meiosis by facilitating homologous recombination and synapsis. It acts in concert with other meiosis-specific proteins such as HORMAD2 forming a complex that ensures genetic material is evenly exchanged and segregated. This process is important for gametogenesis impacting fertility and genetic diversity.
Pathways
HORMAD1 plays a significant role in the regulatory pathways involved in meiotic checkpoints. It ensures that errors in meiotic processes get detected and corrected by interacting with proteins like ATM and ATR which are important for DNA damage repair. These pathways sustain genome stability during the transmission of genetic information.
Improper function or regulation of HORMAD1 relates to reproductive issues notably infertility due to defective gametogenesis. Additionally studies suggest HORMAD1 overexpression in certain cancers such as breast cancer potentially affecting homologous recombination processes. This is often associated with the BRCA1 and BRCA2 proteins highlighting its connection to DNA repair pathways and cancer progression.