Abcam, ab220665, Anti-Evx1 antibody

Size: 100µL
Rabbit Polyclonal EVX1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EVX1 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EVX1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.P49640

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Evx1 also known as Even-Skipped Homeobox 1 acts as a transcription factor involved in multiple developmental processes. It belongs to the homeobox gene family and is characterized by a 43 kilodalton mass. Researchers have found Evx1 highly expressed in the embryonic tissue of vertebrates notably in motor neurons and dorsal neural tube regions during early stages of development. Its expression regulates patterns necessary for embryonic morphogenesis and differentiation.
Biological function summary
Evx1 plays a significant role in the regulation of genes essential for embryonic development particularly those involved in neural differentiation and segmentation. This protein interacts with other proteins and forms complexes that modulate gene expression needed for spinal cord development. By influencing the expression of important target genes Evx1 mediates processes important for proper neuronal identity and migration.
Pathways
Evx1 influences several key developmental pathways including the Wnt signaling and Notch signaling pathways. In the Wnt signaling pathway Evx1 interacts with the Wnt proteins to regulate gene transcription and ensure proper pattern formation. Similarly in the Notch signaling pathway Evx1 works alongside Notch proteins contributing to the cell fate decisions and segmental organization. These interactions highlight Evx1's integral role in the precise coordination of embryonic development.
Evx1 has associations with certain developmental abnormalities notably caudal dysgenesis and spina bifida. Such conditions often result from disruptions in normal Evx1 function affecting proper spinal cord formation. The target gene's association with the Wnt and Notch pathways along with proteins like β-catenin and Notch1 links it to these disorders highlighting its importance in maintaining developmental integrity and preventing pathological outcomes.