Abcam, ab220675, Anti-p37 antibody

Size: 100µL
Rabbit Polyclonal p37 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NUP37 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NUP37 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8NFH4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The p37 protein also known as the Mycoplasma pneumoniae protein has a mass of approximately 37 kDa. It functions mechanically as a surface antigen and a membrane-associated protein. Researchers express p37 in Mycoplasma species with noted presence in Mycoplasma pneumoniae and Mycoplasma genitalium. This protein facilitates the adherence of the mycoplasma to host cells an important step in infection processes. Observations reveal that p37 contains several domains that are important for its activity at the membrane surface.
Biological function summary
The p37 protein functions in the adherence of Mycoplasma pneumoniae to host epithelial cells. It plays an essential role in the initial stages of infection by facilitating bacterial attachment and colonization. p37 does not form part of a larger protein complex but interacts dynamically with several cellular components. Its ability to mediate host-pathogen interactions makes it an important element in understanding pathogenesis mechanisms of mycoplasma infections. Studies show that p37 can also interfere with host immune responses aiding bacterial survival and persistence.
Pathways
P37's involvement concerns several interaction pathways. Primarily it partakes in the processes of bacterial adhesion and pathogenesis within the host. These pathways are integral for the host-pathogen interaction and often link to cellular signaling pathways that regulate immune responses. Proteins related to these pathways include P1 adhesin another Mycoplasma pneumoniae surface protein that collaborates with p37 to promote binding to host cells. Through these interactions p37 and its related proteins collectively enhance the bacterial pathogenic potential.
The p37 protein contributes significantly to Mycoplasma pneumoniae-associated respiratory tract infections and to a lesser extent urethritis caused by Mycoplasma genitalium. These infections can result in extended periods of illness primarily when untreated. In association with respiratory infections p37 interacts with proteins such as P1 adhesin which work jointly to ensure sustainable colonization within the host. Understanding these interactions helps identify potential therapeutic targets for managing infections caused by these pathogens.