Abcam, ab220729, Anti-TMCO1 antibody

Size: 100µL
Rabbit Polyclonal TMCO1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMCO1 aa 150-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMCO1 aa 150-200. The exact immunogen used to generate this antibody is proprietary information.Q9UM00

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMCO1 also known as Transmembrane and Coiled-Coil Domains 1 functions primarily as a calcium leak channel within the endoplasmic reticulum. It facilitates the regulation of calcium homeostasis by allowing the passive release of calcium ions with a molecular weight of approximately 28 kDa. TMCO1 is expressed in various tissues including the brain heart and skeletal muscles pointing towards its widespread role in cellular calcium management.
Biological function summary
TMCO1 plays an essential role in maintaining intracellular calcium balance which is important for various cellular processes such as muscle contraction neurotransmission and enzyme activity regulation. TMCO1 does not usually operate as an isolated entity but can interact with other components to form functional complexes that regulate calcium dynamics. This protein ensures that calcium concentrations within cells remain balanced preventing overload and allowing cells to function properly.
Pathways
TMCO1 integrates with calcium signaling and homeostasis pathways. It functions alongside calcium-binding proteins and transporters that maintain optimal calcium levels influencing processes from signal transduction to energy metabolism. TMCO1 works in coordination with proteins such as STIM1 and ORAI1 in these pathways which are pivotal in store-operated calcium entry (SOCE) mechanisms linking it to both calcium influx and release pathways.
TMCO1 mutations or dysregulation can contribute to conditions like dental enamel hypoplasia and eye defects often classified under TMCO1 deficiency disorders. This protein can also be related to neurodegenerative diseases through dysfunctional calcium homeostasis which might link it indirectly with proteins such as amyloid-beta precursor protein (APP) in Alzheimer's pathology. Understanding these interactions aids in deciphering how perturbations in TMCO1 activity can lead to disease states.