Abcam, ab220827, Anti-Senataxin antibody

Size: 100µL
Rabbit Polyclonal Senataxin antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SETX aa 200-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SETX aa 200-400. The exact immunogen used to generate this antibody is proprietary information.Q7Z333

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Senataxin also known as SETX is an RNA/DNA helicase enzyme that manages the resolution of R-loops during transcription. The protein has a molecular mass of approximately 302 kDa. SETX is expressed widely across various tissues including high levels in neural tissue. As a helicase it ensures the proper maintenance and stability of the genome by unwinding nucleic acid structures which is essential for transcription replication and DNA repair processes.
Biological function summary
SETX plays an important role in preventing genomic instability. It participates in RNA processing events and transcription termination where it helps resolve R-loop structures that can impede transcription. SETX also functions within protein complexes involved in the regulation of oxidative stress responses. Its interactions with other RNA-binding proteins facilitate its role in these processes ensuring efficient gene expression and cellular homeostasis.
Pathways
SETX contributes significantly to transcriptional regulation and DNA damage response pathways. In the transcription termination pathway it works alongside exonucleases and other helicases to prevent aberrant transcriptional readthrough. SETX is related to proteins like RNAPII assisting in the resolution of transcription-associated R-loops and also associating with factors involved in the DNA damage response pathway to repair transcription-blocking lesions.
SETX mutations have links to neurological conditions such as Amyotrophic Lateral Sclerosis 4 (ALS4) and Ataxia Oculomotor Apraxia 2 (AOA2). These diseases relate to disrupted helicase activity leading to genomic instability and neuronal damage. In ALS4 altered interactions between SETX and other proteins like TDP-43 can contribute to motor neuron degeneration while in AOA2 the impaired role of SETX in DNA repair results in neurological symptoms.