Abcam, ab221097, Anti-MSC antibody

Size: 100µL
Rabbit Polyclonal MSC antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MSC aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MSC aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O60682

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The biological target MSC short for Mesenchymal Stem Cell is a multipotent stromal cell capable of differentiating into a variety of cell types including osteoblasts chondrocytes and adipocytes. MSCs usually express surface markers such as CD73 CD90 and CD105 while lacking expression of hematopoietic markers like CD45 and CD34. These cells are primarily found in the bone marrow but are also present in adipose tissue umbilical cord blood and other tissues. MSCs typically range in size from 15 to 30 µm and play a significant role in tissue homeostasis and repair.
Biological function summary
MSCs engage in critical roles concerning tissue regeneration and immune modulation. MSCs interact within a complex cellular microenvironment to promote healing by secreting a variety of cytokines and growth factors. These cells aid in the down-regulation of immune responses which is vital for transplantation tolerance and autoimmunity treatment. While they are not strictly part of a single cellular complex their interactions with immune cells such as T-cells and dendritic cells highlight their multifaceted functionality.
Pathways
Mesenchymal Stem Cells participate in the Wnt/β-catenin and TGF-β signaling pathways. In the Wnt/β-catenin pathway MSCs influence cell proliferation and differentiation engaging proteins such as β-catenin and glycogen synthase kinase 3β (GSK-3β). In the context of the TGF-β pathway MSCs are involved in the regulation of extracellular matrix production and maintenance interacting with proteins like SMAD2/3 to convey signals essential for cellular processes. These pathways underline MSCs' involvement in both regenerative and regulatory roles in various tissue contexts.
MSCs show promise in treating osteoarthritis and graft-versus-host disease due to their regenerative and immunomodulatory properties. In osteoarthritis MSCs contribute to cartilage repair and anti-inflammatory modulation working in conjunction with proteins like matrix metalloproteinases (MMPs) to restore joint function. For graft-versus-host disease MSCs help mitigate immune reactions via interactions with T-cell receptors creating an environment conducive to tissue repair and immune tolerance. These associations highlight MSCs as potential therapeutic agents in regenerative medicine.