Abcam, ab221167, Anti-UBXN6/UBXD1 antibody

Size: 100µL
Rabbit Polyclonal UBXN6/UBXD1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human UBXN6 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human UBXN6 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9BZV1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UBXN6 also known as UBXD1 is a protein with a molecular mass of approximately 48 kDa. This protein is expressed across various tissues showing higher levels in skeletal muscle heart and kidney. UBXN6 contains a UBX domain which is essential for its interactions with other proteins especially those in the ubiquitin-proteasome system. Mechanically UBXN6 acts as a cofactor modulating the functions of several cellular machineries involved in protein degradation.
Biological function summary
UBXN6 plays an important role in the regulation of protein turnover as it is involved in the ubiquitin-proteasome complex. It assists in the disassembly of protein substrates tagged for degradation contributing to the maintenance of protein quality control within the cell. Through interaction with p97/VCP UBXN6 helps in processes like endoplasmic reticulum-associated degradation (ERAD) important for cellular response to misfolded proteins.
Pathways
UBXN6's involvement extends to the autophagy and ubiquitin-proteasome pathways. In the ubiquitin-proteasome pathway it acts as a regulatory component favoring the removal of damaged or unnecessary proteins by acting with partners like p97/VCP. Through the autophagy pathway UBXN6 aids in cellular cleanup and recycling processes supporting cellular survival mechanisms during stress conditions. These pathways highlight UBXN6's integral role in protein quality control and cellular defense.
Research links UBXN6 to neurological disorders such as amyotrophic lateral sclerosis (ALS) where misfolded proteins contribute to disease progress. Moreover UBXN6 relates to cancer especially in tumor progression where impaired protein degradation can lead to uncontrolled cell growth. In both cases UBXN6 interacts closely with p97/VCP offering potential therapeutic targets for drug development aimed at modulating its activity to restore cellular balance.